Lemina capitalized on an unmarked opportunity from Pablo Sarabia's corner early in the second half, rewarding Wolves after enduring early pressure and missed chances, notably by Raheem Sterling.
Struggling to regain momentum, Chelsea found it challenging to break through in the final third, with Cole Palmer unable to make a significant impact. In stoppage time, Wolves capitalized on a defensive lapse as Hugo Bueno's cross found Doherty, who capitalized on a poor clearance to secure the second goal.
The game started with an opportunity for Armando Broja, but the Albanian striker missed a chance created by Sterling's setup, failing to convert. Sterling proved to be Chelsea's primary threat in the first half, delivering promising crosses, yet the opportunities were squandered.
Sterling had a chance to exploit Wolves' defense but opted for a weak shot, missing a golden opportunity with teammates well-positioned for a potential tap-in.
Wolves' notable chances came late in the first half, with Sarabia's deflected shot going wide and Hee Chan Hwang's effort flying over the bar.
Into the second half, Wolves displayed urgency, with Joao Gomes and Toti testing Chelsea's goalkeeper Djordje Petrovic, who made crucial saves to deny the hosts.
However, Chelsea failed to react to the warning signs. Lemina's header from Sarabia's corner found the net as no Chelsea player challenged, allowing Wolves to take the lead.
Substitutions injected energy into Chelsea's attack, with Nkunku nearly scoring on his Premier League debut, only to be cleared off the line by Toti.
Sterling and Palmer continued to threaten, but a crucial block from Craig Dawson denied Sterling's attempt, shifting the balance of the game in Chelsea's favor.
In the dying moments, a defensive lapse from Benoit Badiashile allowed Doherty to seal Wolves' victory with a late strike, leaving little time for Chelsea to mount a comeback.
Despite Nkunku's late headed goal from Sterling's cross, it was too late for Chelsea to salvage a result, allowing Wolves to claim the win, placing them level on points with Chelsea but with an inferior goal difference, elevating them to 11th place in the Premier League table.